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Sponsored by: Honors Program
Seminars: Monitoring Protein Synthesis in Space and Time with Ribosome Profiling
Start Date/Time: 1/8/2018 4:00 PM
End Date/Time: 1/8/2018 4:45 PM
Location: Alumni Hall B
Description: I will talk about recent applications of ribosome profiling including: the identification of novel protein coding regions, demonstration of the principle of proportional synthesis of subunits in multiprotein complexes and monitoring localized protein translation. I will also present our work identifying and characterizing the ribosome quality control (RQC) complex which is responsible for degrading nascent chains from failed translation reactions. This will include our discovery of a remarkable mechanism for tagging such nascent chains with carboxy-terminal alanine and threonine extensions (CAT tails) through a noncanonical translation reaction that is independent of mRNA or 40S subunits.
Contact: Josephine Markiewicz
Phone: 263-3815
Email: Josephine.Markiewicz@nyumc.org
Speaker: Jonathan S. Weissman, PhD
Speaker Institution: University of California, SF
Speaker Institution Location: San Francisco CA
Speaker Position: Professor of Cellular Molecular Pharmacology
Addtl. Info: Investigator, Howard Hughes Medical Institute
Seminar Host: Ruth Lehmann
Refreshments: No
Fee Required: No
Fee Amount:

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