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Sponsored by: Honors Program
Seminars: Experience- and Activity-Dependent Development of Cortical Circuits by Genes Linked to Neurodevelopmental Disorders
Start Date/Time: 2/26/2018 4:00 PM
End Date/Time: 2/26/2018 5:00 PM
Location: Alumni Hall B
Description: Sensory experience and learning determine and refine development of specific cortical circuits through a coordinated process of synapse formation, stabilization and elimination. Importantly, in neurodevelopmental disorders, such as schizophrenia and autism, deficits in experience-driven synapse development occur. It has long been hypothesized that experience elicits long-term changes in circuit function through experience- and activity-regulated transcription of genes that remodel synapses. I will present our recent work revealing roles for the MEF2 family of activity-dependent transcription factors in distinct stages of activity- driven synapse elimination and experience-dependent development of specific sensory neocortical circuits. Our work reveals new and unexpected aspects of cortical circuit development and defines new roles for MEF2 and other activity-dependent transcription in these processes.
Contact: Josephine Markiewicz
Phone: 263-3815
Email: Josephine.Markiewicz@nyumc.org
Speaker: Kimberly Huber, PhD
Speaker Institution: UT Southwestern Medical Center
Speaker Institution Location: Dallas, TX
Speaker Position: Professor of Neuroscience
Addtl. Info: Director, Center for Collaborative Research in Fragile X
Seminar Host: Ed Ziff
Refreshments: No
Fee Required: No
Fee Amount:

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