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Sponsored by: Honors Program
Seminars: Oxysterol Regulation of Immune Cell Migration and Metabolism
Start Date/Time: 4/16/2018 4:00 PM
End Date/Time: 4/16/2018 5:00 PM
Location: Alumni Hall B
Description: The Cyster laboratory is interested in immune response dynamics. This involves deciphering the cues that guide immune cell movements within, and egress from, lymphoid organs. GPCRs are a major class of chemoattractant receptor on immune cells and we have used gain- and loss-of function approaches to establish roles for several GPCRs that respond to protein (chemokine) and lipid (sphingosine-1-phosphate (S1P), endocannabinoid, lysophospholipid, and oxysterol) ligands and to study how these responses adapt after exposure to antigen or inflammatory inputs. In the talk I will present work that builds from findings regarding an oxysterol acting as a chemoattractant to show how 25-hydroxycholesterol regulates inflammasome activation and IL1-family cytokine production by restraining cholesterol biosynthesis in macrophages. The talk will also describe our use of scRNAseq to learn about the diversity of stromal cells supporting lymphoid tissue functions.
Contact: Josephine Markiewicz
Phone: 263-3815
Email: Josephine.Markiewicz@nyumc.org
Speaker: Jason Cyster, PhD
Speaker Institution: University of California, SF
Speaker Institution Location: San Francisco CA
Speaker Position: Professor of Microbiology and Immunology
Seminar Host: Dan Littman
Refreshments: No
Fee Required: No
Fee Amount:

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