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Sponsored by: Honors Program
Seminars: Mitochondrial Genome Inheritance and Replacement in the Human Germiline
Start Date/Time: 11/20/2017 4:00 PM
End Date/Time: 11/20/2017 5:00 PM
Location: Alumni Hall B
Description: Mitochondrial disease caused by pathogenic germline mtDNA mutations is maternally transmitted through oocyte. The resulting loss of cellular respiration leads to severe and progressive disorders, involving several different organs with prominent involvement of the central nervous system, cardiac and other tissues with high-energy demands. Mitochondrial replacement therapies (MRT) in oocytes or single-celled embryos were developed that could prevent transmission of mtDNA defects from mothers to their children. Preclinical and clinical studies demonstrated feasibility, efficacy and long-term safety of MRT approaches. Clinical applications of MRT have been recently approved in the UK and currently under consideration in USA.
Contact: Josephine Markiewicz
Phone: 263-3815
Email: Josephine.Markiewicz@nyumc.org
Speaker: Shoukhrat Mitalipov, PhD
Speaker Institution: Oregon Health & Science University
Speaker Institution Location: Portland, OR
Speaker Position: Professor and Director, Center for Embryonic Cell & Gene Therapy
Seminar Host: Ruth Lehmann
Refreshments: No
Fee Required: No
Fee Amount:

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