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Sponsored by: Honors Program
Seminars: Epigenetic and Chromatin Remodeling at the Beginming of Mammalian Life
Start Date/Time: 11/27/2017 4:00 PM
End Date/Time: 11/27/2017 5:00 PM
Location: Alumni Hall B
Description: Mammalian sperm and oocytes have different epigenetic landscapes and are organized in different fashion. Following fertilization, the protamine-packaged sperm genome is assembled into chromatin de novo, while the maternal chromatin is inherited from the egg. During preimplantation development, both genomes go through reprogramming to become largely equal with the exception of imprinted loci. After global DNA demethylation, zygotic genome activation takes place to prepare the embryos for the first cell lineage specification and later embryonic development. Despite their importance, the molecular mechanism underlying these fundamental developmental processes are not well understood due to the limited cell numbers available and technical challenges in studying these processes. Recent advancement in chromatin and high-throughput sequencing techniques make genome-wide chromatin, transcriptome, and epigenetic modifications of mammalian preimplantation embryos possible. In the seminar, I will present some of our efforts aiming to reveal the molecular events underlying mammalian preimplantation development.
Contact: Josephine Markiewicz
Phone: 263-3815
Email: Josephine.Markiewicz@nyumc.org
Speaker: Yi Zhang, PhD
Speaker Institution: Harvard Medical School
Speaker Institution Location: Boston, MA
Speaker Position: Professor of Genetics and of Pediatrics
Addtl. Info: Investigator, Howard Hughes Medical Institute
Seminar Host: Ruth Lehmann
Refreshments: No
Fee Required: No
Fee Amount:
 

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